A total of 7 of the 19 participants (37% 4 CF) had a relative difference in LCI 2.5 > 10% for both migrated and rerun data compared to 3.3.1 collected data. Multiple breath washout (MBW) data directly collected in 3.3.1 was significantly different from both migrated and rerun data. MBWN 2 was performed using the Exhalyzer® D first on the old 3.1.6 software and next, directly on corrected 3.3.1 software. We prospectively recruited 19 participants, 10 adult healthy controls and 9 people with cystic fibrosis (CF). To our knowledge, no research has been published assessing whether either method is equivalent to directly collecting data in the new corrected software.
Within the field there have been discussions on how to correct legacy data, whether to migrate or completely “rerun” raw data A-files from the old software into the new corrected software. Subsequently an updated and corrected software version has been released. This caused an extended tail to the washout, and over-estimated lung clearance index (LCI 2.5) values.
Recently, a cross-talk error with commercial multiple breath nitrogen washout (MBWN 2) software was discovered, which produced an absolute over-reading of N 2 of approximately 1%, i.e., 2% N 2 read as 3%.
0 kommentar(er)
